Liverpool striker Luis Suarez scored four goals – including a superb 20-minute first-half hat-trick – to send the number crunchers into overdrive and Norwich City back to East Anglia disconsolate.
The statistics piling up for the Uruguay international at Anfield are remarkable and surpassed only by his personal record against the Canaries. In the 5-1 victory for the Reds, the 26-year-old became the first Premier League player to score three hat-tricks against the same team.
Suarez now has 11 goals in five appearances against Norwich – and he did not score in his first game against them. Bradley Johnson headed home Nathan Redmond's left-wing cross with seven minutes to go to make it 4-1, but Raheem Sterling ensured the night finished on a high by converting Suarez's cross.
Bryan Oviedo piled the pressure on Manchester United manager David Moyes by slamming home an 85th-minute winner to end Everton's 21-year Old Trafford hoodoo.
Not since 1992 had the Toffees beaten Manchester United away from home. For 11 of those years, as Everton boss, Moyes had been the manager trying to do so.
Oviedo, signed by Moyes last year, arrived with perfect timing at the far post to condemn United to their fourth defeat of the season, which leaves them 12 points adrift of leaders Arsenal.
Nicklas Bendtner scored his first Arsenal goal since March 2011 as the Gunners stayed in control at the top of the table with a 2-0 win over Hull City.
The Denmark striker headed the hosts in front inside two minutes. Mesut Ozil extended Arsenal's lead at the start of the second half, finishing off a fine passing exchange with Aaron Ramsey.
Eden Hazard turned in a virtuoso display as Chelsea came out on top in a 4-3 thriller at Sunderland.
The Belgium international was both provider and scorer on the night, producing the cross from which Frank Lampard cancelled out Jozy Altidore's opener and then two pieces of individual magic to effectively win the game.
After Altidore had given the Black Cats a 14th-minute lead, Chelsea levelled through a Lampard close-range header.
Hazard stole the show, capping a fine individual first-half display with an enterprising 37th-minute run and a sumptuous finish to restore order.
John O'Shea dragged the home side right back into it five minutes into the second half but Hazard was not done and took it upon himself to leave defenders in his wake once again to rifle a 62nd-minute shot past goalkeeper Vito Mannone. There was late drama as home full-back Phil Bardsley scored at both ends inside a minute.
A first Tottenham goal for Vlad Chiriches and a smart strike from Lewis Holtby spared manager Andre Villas-Boas's blushes as his side scrambled a 2-1 victory at Fulham. Rene Meulensteen's reign at the Cottagers had started with Ashkan Dejagah converting Dimitar Berbatov's through ball with a calm finish just before the hour.
First-half goals from Manchester City's Sergio Aguero and Yaya Toure, combined with a penalty from the latter in the second half, were enough to sink West Bromwich Albion 3-2 at The Hawthorns.
The scoreline was made respectable courtesy of an 86th-minute own goal from Costel Pantilimon and a then late stoppage-time strike from Albion's Victor Anichebe.
Fabian Delph's first Premier League goal was one to remember, rifling home from distance to secure Aston Villa a 3-2 victory at Southampton.
Gabriel Agbonlahor showed pace and composure to net the opener for Villa only for Jay Rodriguez to head the Saints level. Villa went ahead through Libor Kozak but Southampton showed character to level through Dani Osvaldo, only for Villa to snatch victory in the 80th minute.
Swansea City ended Newcastle United's four-match winning run with a 3-0 victory over Alan Pardew's side at the Liberty Stadium. Substitute Nathan Dyer, a Mathieu Debuchy own goal and a Jonjo Shelvey strike gave the Swans a second home win this term.